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Articular cartilage defects are caused by multiple reasons such as damage, abuse or genetic predisposition but have in common that they do not heal. They cause pain and require clinical intervention at a certain stage. Especially sports injuries are the reason for movement problems of young patients which particularly require regeneration rather than a replacement of damaged tissue by artificial materials such as metal, ceramics or plastic. Osteoarthritis is prevalent in elderly people and requires a systematic approach including treatment of the surrounding tissues and inflammation. 

Sylvia Nürnberger (Medical University of Vienna, Ludwig Boltzmann Institute for Traumatology, the research center in cooperation with AUVA
Silke Aldrian (Medical University of Vienna
Sigfried Trattnig (Medical University of Vienna
Andreas Traweger (Paracelsus Medical University Salzburg