Publications of 2023 – Austrian Cluster for Tissue Regeneration

Neuroregeneration

de Sousa DMB, Benedetti A, Altendorfer B, Mrowetz H, Unger MS, Schallmoser K, Aigner L, Kniewallner KM.
Immune-mediated platelet depletion augments Alzheimer's disease neuropathological hallmarks in APP-PS1 mice.
Aging (Albany NY). 2023 Feb 1;15(3):630-649.
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Benedetti B, Bieler L, Erhardt-Kreutzer C, Jakubecova D, Benedetti A, Reisinger M, Dannehl D, Thome C, Engelhardt M, Couillard-Despres S.
Depolarization and Hyperexcitability of Cortical Motor Neurons after Spinal Cord Injury Associates with Reduced HCN Channel Activity.
Int J Mol Sci. 2023 Mar 1;24(5):4715.
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Kronsteiner B, Zopf LM, Heimel P, Oberoi G, Kramer AM, Slezak P, Weninger WJ, Podesser BK, Kiss A, Moscato F.
Corrigendum: Mapping the functional anatomy and topography of the cardiac autonomic innervation for selective cardiac neuromodulation using MicroCT.
Front Cell Dev Biol. 2023 Mar 31;11:1193013.
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Millesi F, Mero S, Semmler L, Rad A, Stadlmayr S, Borger A, Supper P, Haertinger M, Ploszczanski L, Windberger U, Weiss T, Naghilou A, Radtke C.
Systematic Comparison of Commercial Hydrogels Revealed That a Synergy of Laminin and Strain-Stiffening Promotes Directed Migration of Neural Cells.
ACS Appl Mater Interfaces. 2023 Mar 15;15(10):12678-12695.
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Semmler L, Naghilou A, Millesi F, Wolf S, Mann A, Stadlmayr S, Mero S, Ploszczanski L, Greutter L, Woehrer A, Placheta-Györi E, Vollrath F, Weiss T, Radtke C.
Silk-in-Silk Nerve Guidance Conduits Enhance Regeneration in a Rat Sciatic Nerve Injury Model.
Adv Healthc Mater. 2023 Apr;12(11):e2203237.

Urmann C, Bieler L, Hackl M, Chia-Leeson O, Couillard-Despres S, Riepl H.
Semi-Synthesis of Different Pyranoflavonoid Backbones and the Neurogenic Potential.
Molecules. 2023 May 11;28(10):4023.
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Leister I, Altendorfer B, Maier D, Mach O, Wutte C, Grillhösl A, Arevalo-Martin A, Garcia-Ovejero D, Aigner L, Grassner L.
Trajectory of Serum Levels of Glial Fibrillary Acidic Protein Within Four Weeks Post-Injury Is Related to Neurological Recovery During the Transition from Acute to Chronic Spinal Cord Injury.
J Neurotrauma. 2023 May;40(9-10):999-1006.

Weidinger A, Milivojev N, Hosmann A, Duvigneau JC, Szabo C, Törö G, Rauter L, Vaglio-Garro A, Mkrtchyan GV, Trofimova L, Sharipov RR, Surin AM, Krasilnikova IA, Pinelis VG, Tretter L, Moldzio R, Bayır H, Kagan VE, Bunik VI, Kozlov AV.
Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death.
Redox Biol. 2023 Jun;62:102669.
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de Sousa DMB, Poupardin R, Villeda SA, Schroer AB, Fröhlich T, Frey V, Staffen W, Mrowetz H, Altendorfer B, Unger MS, Iglseder B, Paulweber B, Trinka E, Cadamuro J, Drerup M, Schallmoser K, Aigner L, Kniewallner KM.
The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study.
Front Mol Biosci. 2023 Jun 30;10:1196083.
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Ghibaudi M, Marchetti N, Vergnano E, La Rosa C, Benedetti B, Couillard-Despres S, Farioli-Vecchioli S, Bonfanti L.
Age-related changes in layer II immature neurons of the murine piriform cortex.
Front Cell Neurosci. 2023 Jul 28;17:1205173.
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Naghilou A, Peter K, Millesi F, Stadlmayr S, Wolf S, Rad A, Semmler L, Supper P, Ploszczanski L, Liu J, Burghammer M, Riekel C, Bismarck A, Backus EHG, Lichtenegger H, Radtke C.
Insights into the material properties of dragline spider silk affecting Schwann cell migration.
Int J Biol Macromol. 2023 Jul 31;244:125398.

Saravi B, Ülkümen S, Lang G, Couillard-Després S, Hassel F.
Case-matched radiological and clinical outcome evaluation of interlaminar versus microsurgical decompression of lumbar spinal stenosis.
Eur Spine J. 2023 Aug;32(8):2863-2874.

Saravi B, Zink A, Ülkümen S, Couillard-Despres S, Wollborn J, Lang G, Hassel F.
Automated Detection and Measurement of Dural Sack Cross-Sectional Area in Lumbar Spine MRI Using Deep Learning.
Bioengineering (Basel). 2023 Sep 10;10(9):1072.
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Tomou EM, Bieler L, Spöttl T, Couillard-Despres S, Skaltsa H, Urmann C.
Metabolic Fingerprinting of Different Sideritis Taxa Infusions and Their Neurogenic Activity.
Planta Med. 2023 Sep;89(11):1087-1096.

Praschl C, Zopf LM, Kiemeyer E, Langthallner I, Ritzberger D, Slowak A, Weigl M, Blüml V, Nešić N, Stojmenović M, Kniewallner KM, Aigner L, Winkler S, Walter A.
U-Net based vessel segmentation for murine brains with small micro-magnetic resonance imaging reference datasets.
PLoS One. 2023 Oct 12;18(10):e0291946.
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Saravi B, Guzel HE, Zink A, Ülkümen S, Couillard-Despres S, Wollborn J, Lang G, Hassel F.
Synthetic 3D Spinal Vertebrae Reconstruction from Biplanar X-rays Utilizing Generative Adversarial Networks.
J Pers Med. 2023 Nov 24;13(12):1642.
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Benedetti B, Reisinger M, Hochwartner M, Gabriele G, Jakubecova D, Benedetti A, Bonfanti L, Couillard-Despres S.
The awakening of dormant neuronal precursors in the adult and aged brain.
Aging Cell. 2023 Dec;22(12):e13974.
(free PDF)

Soft Tissue & Skin Regeneration

Panahipour L, Oladzad Abbasabadi A, Gruber R.
Oral Cell Lysates Reduce the Inflammatory Response of Activated Macrophages.
J Clin Med. 2023 Feb 20;12(4):1701.
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Strickland AD, Lang C, Manhartseder S, Reichsoellner R, Valliant E, Schädl B, Gulle H, Slezak P.
In vitro and Ex vivo Assessments of the Compatibility of Fibrin Sealant with Antimicrobial Compounds.
Surg Infect (Larchmt). 2023 Feb;24(1):82-90.
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Dungel P, Sutalo S, Slezak C, Keibl C, Schädl B, Schnidar H, Metzger M, Meixner B, Hartmann J, Oesterreicher J, Redl H, Slezak P.
Wavelength-Dependent Effects of Photobiomodulation for Wound Care in Diabetic Wounds.
Int J Mol Sci. 2023 Mar 20;24(6):5895.
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Tomasch J, Maleiner B, Hromada C, Szwarc-Hofbauer D, Teuschl-Woller AH.
Cyclic Tensile Stress Induces Skeletal Muscle Hypertrophy and Myonuclear Accretion in a 3D Model.
Tissue Eng Part A. 2023 May;29(9-10):257-268.

Swolin-Eide D, Forsander G, Pundziute Lyckå A, Novak D, Grillari J, Diendorfer AB, Hackl M, Magnusson P.
Circulating microRNAs in young individuals with long-duration type 1 diabetes in comparison with healthy controls.
Sci Rep. 2023 Jul 19;13(1):11634.
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Alharbi Z, Qari S, Almarzouqi F, Khatib K, Tsolakidis S, Fathuldeen A, Grieb G, Rennekampff HO.
Reconstruction of Upper and Lower Limb Defects with Medial Sural Artery Perforator Flaps: Is Aesthetics Worth the Effort? A Retrospective Analysis.
Surg J (N Y). 2023 Jul 10;9(3):e82-e88.
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Al-Sharabi N, Gruber R, Sanz M, Mohamed-Ahmed S, Kristoffersen EK, Mustafa K, Shanbhag S.
Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin.
Int J Mol Sci. 2023 Aug 22;24(17):13057
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Panahipour L, Botta S, Abbasabadi AO, Afradi Z, Gruber R.
Enamel Matrix Derivative Suppresses Chemokine Expression in Oral Epithelial Cells.
Int J Mol Sci. 2023 Sep 12;24(18):13991.
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Panahipour L, Croci R, Guarnieri S, Gruber R.
PRF Lysates Enhance the Proliferation and Migration of Oral Squamous Carcinoma Cell Lines.
Dent J (Basel). 2023 Oct 19;11(10):242.
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Holub O, Schanda JE, Boesmueller S, Tödtling M, Talaska A, Kinsky RM, Mittermayr R, Fialka C.
Glenohumeral Pathologies following Primary Anterior Traumatic Shoulder Dislocation-Comparison of Magnetic Resonance Arthrography and Arthroscopy.
J Clin Med. 2023 Oct 24;12(21):6707.
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Panahipour L, Abbasabadi AO, Gruber R.
Gingival Fibroblasts Are Sensitive to Oral Cell Lysates Indicated by Their IL11 Expression.
Bioengineering (Basel). 2023 Oct 13;10(10):1193.
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Ernst AM, Steiner M, Kainz V, Tempfer H, Spitzer G, Plank T, Bauer HC, Bresgen N, Habenbacher A, Bauer H, Lipp AT.
Lipedema: The Use of Cultured Adipocytes for Identification of Diagnostic Markers.
Plast Reconstr Surg. 2023 Nov 1;152(5):1036-1046.

Bone & Ligament Regeneration

Shao F, Panahipour L, Gruber R.
Flavonoids from Dalbergia cochinchinensis: Impact on osteoclastogenesis.
J Dent Sci. 2023 Jan;18(1):112-119.
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Jenner F, Wagner A, Gerner I, Ludewig E, Trujanovic R, Rohde E, von Rechenberg B, Gimona M, Traweger A.
Evaluation of the Potential of Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles to Improve Rotator Cuff Healing: A Pilot Ovine Study.
Am J Sports Med. 2023 Feb;51(2):331-342.

Michels R, Kampleitner C, Dobsak T, Doppelmayer K, Heimel P, Lettner S, Tangl S, Gruber R, Benfatti CAM.
Impact of a Static Magnetic Field on Early Osseointegration: A Pilot Study in Canines.
Materials (Basel). 2023 Feb 23;16(5):1846.
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Shanbhag S, Kampleitner C, Al-Sharabi N, Mohamed-Ahmed S, Apaza Alccayhuaman KA, Heimel P, Tangl S, Beinlich A, Rana N, Sanz M, Kristoffersen EK, Mustafa K, Gruber R.
Functionalizing Collagen Membranes with MSC-Conditioned Media Promotes Guided Bone Regeneration in Rat Calvarial Defects.
Cells. 2023 Feb 28;12(5):767.
(free PDF)

Apaza Alccayhuaman KA, Heimel P, Lee JS, Tangl S, Kuchler U, Marchesan J, Panahipour L, Lettner S, Matalová E, Gruber R.
FasL is a catabolic factor in alveolar bone homeostasis.
J Clin Periodontol. 2023 Mar;50(3):396-405.
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Deluca A, Wagner A, Faustini B, Weissenbacher N, Deininger C, Wichlas F, Tempfer H, Mueller EJ, Traweger A.
Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur.
Bioengineering (Basel). 2023 Mar 7;10(3):338.
(free PDF)

Messner Z, Carro Vázquez D, Haschka J, Grillari J, Resch H, Muschitz C, Pietschmann P, Zwerina J, Hackl M, Kocijan R.
Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis-the MiDeTe study.
J Clin Endocrinol Metab. 2023 Apr 13;108(5):1154-1165.
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Struppe A, Schanda JE, Baierl A, Watzl P, Muschitz C.
Impact of Intravenous Iron Substitution on Serum Phosphate Levels and Bone Turnover Markers-An Open-Label Pilot Study.
Nutrients. 2023 Jun 9;15(12):2693.
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Quadlbauer S, Pezzei C, Jurkowitsch J, Beer T, Moser V, Rosenauer R, Salminger S, Hausner T, Leixnering M.
Double screw versus angular stable plate fixation of scaphoid waist nonunions in combination with intraoperative extracorporeal shockwave therapy (ESWT).
Arch Orthop Trauma Surg. 2023 Jul;143(7):4565-4574.

Hanetseder D, Levstek T, Teuschl-Woller AH, Frank JK, Schaedl B, Redl H, Marolt Presen D.
Engineering of extracellular matrix from human iPSC-mesenchymal progenitors to enhance osteogenic capacity of human bone marrow stromal cells independent of their age.
Front Bioeng Biotechnol. 2023 Aug 2;11:1214019.
(free PDF)

Panahipour L, Abbasabadi AO, Wagner A, Kratochwill K, Pichler M, Gruber R.
Bone Allograft Acid Lysates Change the Genetic Signature of Gingival Fibroblasts.
Int J Mol Sci. 2023 Nov 10;24(22):16181.
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Feher B, Kampleitner C, Heimel P, Tangl S, Helms JA, Kuchler U, Gruber R.
The effect of osteocyte-derived RANKL on bone graft remodeling: An in vivo experimental study.
Clin Oral Implants Res. 2023 Dec;34(12):1417-1427.
(free PDF)

Cartilage & Tendon Regeneration

Schneider C, Nürnberger S.
Decellularization of Articular Cartilage: A Hydrochloric Acid-Based Strategy.
Methods Mol Biol. 2023;2598:301-311.

Zak L, Kleiner A, Trattnig S, Albrecht C, Aldrian S.
Long-term Assessment of Subchondral Bone Changes and Intralesional Bony Overgrowth After Third-Generation Autologous Chondrocyte Implantation: A Retrospective Study.
Am J Sports Med. 2023 May;51(6):1414-1421.
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Soukup R, Gerner I, Mohr T, Gueltekin S, Grillari J, Jenner F.
Mesenchymal Stem Cell Conditioned Medium Modulates Inflammation in Tenocytes: Complete Conditioned Medium Has Superior Therapeutic Efficacy than Its Extracellular Vesicle Fraction.
Int J Mol Sci. 2023 Jun 29;24(13):10857.
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Schanda JE, Eigenschink M, Laky B, Frank JK, Pauzenberger L, Anderl W, Heuberer PR.
Comparison of Outcomes After Arthroscopic Superior Capsule Reconstruction Versus Arthroscopic Partial Repair or Arthroscopic Debridement for Irreparable Rotator Cuff Tears.
Orthop J Sports Med. 2023 Jul 28;11(7):23259671231185182.
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Ritter J, Menger M, Herath SC, Histing T, Kolbenschlag J, Daigeler A, Heinzel JC, Prahm C.
Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device - a narrative review.
Front Med (Lausanne). 2023 Oct 6;10:1255215
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Aging Research

Nosrati F, Grillari J, Azarnia M, Nabiuni M, Moghadasali R, Karimzadeh L, Lämmermann I.
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells.
Biogerontology. 2023 Apr;24(2):293-301.
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Ogrodnik M, Gladyshev VN.
The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations.
Nat Aging. 2023 Jul;3(7):766-775.
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Mrowetz H, Kotob MH, Forster J, Aydin I, Unger MS, Lubec J, Hussein AM, Malikovic J, Feyissa DD, Korz V, Höger H, Lubec G, Aigner L.
Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study.
Front Aging Neurosci. 2023 Aug 2;15:1140708.
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Technology Platforms

Aigner P, Sella Bart E, Panfili S, Körner T, Mach M, Andreas M, Königshofer M, Saitta S, Redaelli A, Schmid A, Moscato F.
Quantification of paravalvular leaks associated with TAVI implants using 4D MRI in an aortic root phantom made possible by the use of 3D printing.
Front Cardiovasc Med. 2023 Jan 19;10:1083300.
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Greistorfer S, von Byern J, Miller I, Meyer-Rochow VB, Farkas R, Steiner G.
A histochemical and morphological study of the mucus producing pedal gland system in Latia neritoides (Mollusca; Gastropoda; Hygrophila).
Zoology (Jena). 2023 Feb;156:126067.
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Falkner F, Mayer SA, Thomas B, Zimmermann SO, Walter S, Heimel P, Thiele W, Sleeman JP, Bigdeli AK, Kiss H, Podesser BK, Kneser U, Bergmeister H, Schneider KH.
Acellular Human Placenta Small-Diameter Vessels as a Favorable Source of Super-Microsurgical Vascular Replacements: A Proof of Concept.
Bioengineering (Basel). 2023 Mar 7;10(3):337.
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Schlöglhofer T, Grausenburger AS, Widhalm G, Haberl L, Suda W, Schwingenschlögl H, Riebandt J, Laufer G, Wiedemann D, Moscato F, Zimpfer D, Schima H.
It's not only the pump: Assessment of human factors of wearable components and user experience of patients with left ventricular assist devices.
J Heart Lung Transplant. 2023 Apr;42(4):466-477.
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Reichsöllner R, Heher P, Hartmann J, Manhartseder S, Singh R, Gulle H, Slezak P.
A comparative high-resolution physicochemical analysis of commercially available fibrin sealants: Impact of sealant osmolality on biological performance.
J Biomed Mater Res A. 2023 Apr;111(4):488-501.
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Zandrini T, Florczak S, Levato R, Ovsianikov A.
Breaking the resolution limits of 3D bioprinting: future opportunities and present challenges.
Trends Biotechnol. 2023 May;41(5):604-614.
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Biglino G, Hopfner C, Lindhardt J, Moscato F, Munuera J, Oberoi G, Tel A, Esteve AV.
Perspectives on medical 3D printing at the point-of-care from the new European 3D Printing Special Interest Group.
3D Print Med. 2023 May 5;9(1):14.
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Rocchi M, Gross C, Moscato F, Schlöglhofer T, Meyns B, Fresiello L.
An in vitro model to study suction events by a ventricular assist device: validation with clinical data.
Front Physiol. 2023 Jul 25;14:1155032.
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Tel A, Kornfellner E, Moscato F, Vinayahalingam S, Xi T, Arboit L, Robiony M.
Optimizing efficiency in the creation of patient-specific plates through field-driven generative design in maxillofacial surgery.
Sci Rep. 2023 Jul 26;13(1):12082.
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Guillaume O, Kopinski-Grünwald O, Weisgrab G, Baumgartner T, Arslan A, Whitmore K, Van Vlierberghe S, Ovsianikov A.
Hybrid spheroid microscaffolds as modular tissue units to build macro-tissue assemblies for tissue engineering.
Acta Biomater. 2023 Jul 15;165:72-85.
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Berger L, Haberbusch M, Moscato F.
Generative adversarial networks in electrocardiogram synthesis: Recent developments and challenges.
Artif Intell Med. 2023 Sep;143:102632.
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Schneider KH, Oberoi G, Unger E, Janjic K, Rohringer S, Heber S, Agis H, Schedle A, Kiss H, Podesser BK, Windhager R, Toegel S, Moscato F.
Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity.
3D Print Med. 2023 Sep 28;9(1):27.
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Rohringer S, Grasl C, Ehrmann K, Hager P, Hahn C, Specht SJ, Walter I, Schneider KH, Zopf LM, Baudis S, Liska R, Schima H, Podesser BK, Bergmeister H.
Biodegradable, Self-Reinforcing Vascular Grafts for In Situ Tissue Engineering Approaches.
Adv Healthc Mater. 2023 Sep;12(23):e2300520.
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Wu EL, Maw M, Stephens AF, Stevens MC, Fraser JF, Tansley G, Moscato F, Gregory SD.
Estimation of Left Ventricular Stroke Work for Rotary Left Ventricular Assist Devices.
ASAIO J. 2023 Sep 1;69(9):817-826.

Van Ombergen A, Chalupa-Gantner F, Chansoria P, Colosimo BM, Costantini M, Domingos M, Dufour A, De Maria C, Groll J, Jungst T, Levato R, Malda J, Margarita A, Marquette C, Ovsianikov A, Petiot E, Read S, Surdo L, Swieszkowski W, Vozzi G, Windisch J, Zenobi-Wong M, Gelinsky M.
3D Bioprinting in Microgravity: Opportunities, Challenges, and Possible Applications in Space.
Adv Healthc Mater. 2023 Sep;12(23):e2300443.
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Schlöglhofer T, Gross C, Moscato F, Neumayer A, Kandioler E, Leithner D, Skoumal M, Laufer G, Wiedemann D, Schima H, Zimpfer D, Marko C.
Exercise Performance and Quality of Life of Left Ventricular Assist Device Patients After Long-Term Outpatient Cardiac Rehabilitation.
J Cardiopulm Rehabil Prev. 2023 Sep 1;43(5):346-353.

Zipperle J, Oesterreicher J, Hackl M, Krammer TL, Thumfart H, Bobbili MR, Wiegele M, Grillari J, Osuchowski MF, Schöchl H, Holnthoner W, Schlimp CJ, Schiefer J, Pesce MV, Ulbing S, Gratz J.
Circulating endothelial extracellular vesicle signatures correspond with ICU requirement: an exploratory study in COVID-19 patients.
Intensive Care Med Exp. 2023 Nov 30;11(1):85.
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Janev A, Banerjee A, Weidinger A, Dimec J, Leskošek B, Silini AR, Cirman T, Wolbank S, Ramuta TŽ, Jerman UD, Pandolfi A, Di Pietro R, Pozzobon M, Giebel B, Eissner G, Ferk P, Lang-Olip I, Alviano F, Soritau O, Parolini O, Kreft ME.
Recommendations from the COST action CA17116 (SPRINT) for the standardization of perinatal derivative preparation and in vitro testing.
Front Bioeng Biotechnol. 2023 Nov 14;11:1258753.
(free PDF)

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